Sevelamer carbonate is a phosphate binder medication used to control high phosphate levels in patients with chronic kidney disease (CKD), particularly those on dialysis. It binds to dietary phosphate in the gastrointestinal tract, reducing its absorption into the bloodstream. This helps to manage hyperphosphatemia, a common complication in CKD that can lead to bone disease and cardiovascular problems.
Key Features:
- Mechanism of Action: Sevelamer carbonate binds to phosphate in the digestive tract, forming a non-absorbable complex that is excreted in the feces.
- Form: Available as oral tablets or powder for suspension.
- Non-Calcium, Non-Metal-Based: Unlike some other phosphate binders, it does not contain calcium, aluminum, or other metals, reducing the risk of certain side effects like hypercalcemia or metal toxicity.
Common Side Effects:
- Gastrointestinal issues (e.g., nausea, vomiting, diarrhea, constipation, abdominal pain).
- Indigestion or dyspepsia.
- Rarely, bowel obstruction or perforation (in severe cases).
Important Considerations:
- Should be taken with meals to maximize phosphate-binding efficacy.
- Not recommended for patients with bowel obstruction or hypophosphatemia.
- May interact with other medications (e.g., reduce the absorption of certain drugs like levothyroxine or ciprofloxacin).
Always consult a healthcare provider for proper dosing, administration, and monitoring while using sevelamer carbonate.