Mefloquine is a trusted antimalarial medication frequently prescribed for both preventing and treating malaria infections.
It is especially effective against Plasmodium falciparum, the parasite responsible for the most dangerous type of malaria.
Travelers heading to regions with chloroquine-resistant malaria strains often rely on mefloquine for its strong preventive capabilities.
Key Information About Mefloquine:
Usage:
• Prevention: Administered once a week, starting 1–2 weeks before entering a malaria-endemic area. Continued during the stay and for 4 weeks after departure.
• Treatment: Prescribed for active malaria infections, sometimes in combination with other antimalarials to enhance efficacy.
Dosage Guidelines:
• Preventive Dose: Standard adult dosage is 250 mg once per week.
• Treatment Dose: May vary depending on the patient’s weight and severity of infection. Dosing must be adjusted under medical supervision.
Possible Side Effects:
• Common: Nausea, dizziness, headaches, and sleep issues such as insomnia or vivid dreams.
• Serious (but rare): Neuropsychiatric symptoms including anxiety, depression, confusion, hallucinations, and seizures. These may persist even after discontinuation.
Who Should Avoid Mefloquine:
• Individuals with a history of mental health disorders, epilepsy, or heart problems should not use mefloquine.
• Pregnant women, especially in the first trimester, should only take it if the health benefits outweigh potential risks.
Precautionary Measures:
• Patients must be warned about potential psychological effects and advised to stop the drug if unusual symptoms occur.
• Ongoing monitoring for adverse effects is recommended, especially during long-term use.
Drug Interactions:
Mefloquine can interact with other drugs such as anticoagulants, antiepileptics, and some antibiotics. Always inform your doctor of any current medications.
Critical Considerations:
• Resistance: Some malaria strains have developed resistance to mefloquine. Therefore, additional protective measures like mosquito nets and repellents are strongly advised.
• Compliance: Adhering to the correct dosing schedule is vital to avoid treatment failure and resistance.
Final Reminder:
Consult your healthcare provider to determine whether mefloquine is appropriate for your needs, especially if you have existing health conditions or are taking other medications.
