Azilsartan medoxomil and chlorthalidone are a prescription combination used to manage high blood pressure (hypertension). It combines two medications that work together to lower blood pressure more effectively than either alone.
How the Combination Works
1. Azilsartan Medoxomil (ARB)
- Class: Angiotensin II Receptor Blocker (ARB)
- Mechanism: Blocks angiotensin II, a hormone that tightens blood vessels. This leads to vasodilation and reduced blood pressure.
- Effect: Prevents blood vessel constriction, allowing smoother blood flow.
2. Chlorthalidone (Diuretic)
- Class: Thiazide-like diuretic
- Mechanism: Helps the kidneys remove excess salt and water.
- Effect: Lowers fluid volume and relaxes blood vessels, contributing to blood pressure control.
Why Use This Combination?
This medication is often prescribed when a single drug does not sufficiently control hypertension. Azilsartan and chlorthalidone provide synergistic effects, improving outcomes better than either drug alone.
Common Formulations:
- Azilsartan Medoxomil 40 mg + Chlorthalidone 12.5 mg
- Azilsartan Medoxomil 40 mg + Chlorthalidone 25 mg
Always follow your healthcare provider’s instructions regarding dosage.
Azilsartan Medoxomil + Chlorthalidone Common Side Effects
- Dizziness or lightheadedness
- Increased urination
- Fatigue or tiredness
- Electrolyte imbalances (e.g., low potassium or low sodium)
- Dehydration, especially in warm weather or with excessive fluid loss
Azilsartan Medoxomil + Chlorthalidone Serious Risks & Precautions
- May lead to kidney problems or elevated potassium levels
- Avoid potassium supplements or salt substitutes unless specifically recommended
- Notify your doctor if you have kidney disease, liver problems, diabetes, or if you are pregnant or breastfeeding
- Routine monitoring of blood pressure, electrolyte levels, and kidney function may be required
Brand Name
This medication combination is marketed under the brand name Edarbyclor in the United States.
Important: Always consult your Medical professional before starting, changing, or stopping any prescribed medication.