Amoxicillin + Clavulanate is a powerful combination of antibiotics for treating many bacterial infections. It pairs the effectiveness of a penicillin-based antibiotic with a beta-lactamase inhibitor, making it effective even against bacteria that are resistant to standard antibiotics.
What Is Amoxicillin + Clavulanate?
- Amoxicillin: A penicillin-type antibiotic that kills bacteria by inhibiting cell wall synthesis.
- Clavulanate (Clavulanic acid): Prevents bacterial enzymes (beta-lactamases) from breaking down amoxicillin, boosting its effectiveness against resistant strains.
Together, they are more potent than amoxicillin alone.
Common Brand Names
- Augmentin (most widely known)
- Other regional brands may vary
Uses
This combination is prescribed for infections caused by beta-lactamase-producing bacteria, including:
- Respiratory infections (e.g., sinusitis, bronchitis, pneumonia)
- Ear infections (otitis media)
- Urinary tract infections (UTIs)
- Skin and soft tissue infections
- Dental infections
- Bone and joint infections
Dosage & Administration
- Dosage depends on the type and severity of infection, as well as age, weight, and kidney function.
- Available in several forms:
- Tablets
- Chewable tablets
- Oral suspensions (especially for children)
Always follow your doctor’s instructions and finish the full course.
Common Side Effects
- Diarrhea
- Nausea or vomiting
- Abdominal discomfort
- Rash or skin irritation
- Headache
Less Common but Serious Reactions
- Severe allergic reactions (e.g., swelling, difficulty breathing)
- Liver issues (e.g., jaundice, elevated liver enzymes)
- C. difficile-associated diarrhea (persistent or severe diarrhea)
Precautions
Before using, inform your doctor if you have:
- Penicillin or cephalosporin allergy
- Kidney or liver disease
- Mononucleosis (increases risk of rash)
Drug Interactions
- Probenecid: May increase amoxicillin concentration
- Oral contraceptives: May reduce their effectiveness
- Methotrexate: Increased toxicity risk
- Warfarin: May enhance anticoagulant effects
Important Usage Tips
- Complete the entire antibiotic course — even if symptoms improve early.
- Shake oral suspension well before each use.
- Store medication as directed (some suspensions require refrigeration).
- Speak with your healthcare provider or pharmacist for guidance if you miss a dose.
Conclusion
Amoxicillin + Clavulanate is a trusted and widely used antibiotic combination that expands the coverage of amoxicillin by overcoming bacterial resistance. It’s effective for a variety of common and serious infections when prescribed and used correctly.
Always follow your healthcare provider’s instructions and report any side effects promptly.