Alogliptin and Metformin are a combination oral medication prescribed to help control blood sugar levels in people with type 2 diabetes. Together, these two ingredients target blood glucose through different mechanisms — improving insulin efficiency and reducing sugar production in the liver.
How It Works
Alogliptin (DPP-4 Inhibitor):
- Boosts incretin hormones (GLP-1 and GIP), which:
- Stimulate insulin release after meals
- Reduce glucagon levels to lower blood sugar
Metformin (Biguanide):
- Reduces glucose production in the liver
- Improves insulin sensitivity
- Increases glucose uptake by muscles
Who Should Use It?
- This medication is indicated for adults with type 2 diabetes mellitus.
- This medication is not suitable for the treatment of type 1 diabetes or diabetic ketoacidosis.
How to Take Alogliptin and Metformin
- It is usually taken by mouth once or twice a day with food to help reduce stomach discomfort.
- Dosage depends on individual blood sugar targets and how well the medication is tolerated.
- Always follow your doctor’s instructions and never adjust your dose on your own.
Common Side Effects
- Nausea
- Diarrhea
- Stomach upset
- Headache
Serious Side Effects (Seek Medical Help)
- Lactic acidosis — a rare but serious side effect of metformin (symptoms: muscle pain, fast breathing, stomach pain)
- Pancreatitis (especially with alogliptin — symptoms: severe stomach pain, vomiting)
- Severe allergic reactions (rash, swelling, difficulty breathing)
Precautions
- Avoid if you have severe kidney problems.
- Your doctor might check your kidney function from time to time to ensure everything’s working properly.
- Inform your doctor if you’ve had heart failure or pancreatitis.
Drug Interactions
- Let your healthcare provider know if you’re taking:
- Diuretics
- Corticosteroids
- Heart medications
- Contrast dyes (used for imaging tests)
Important Safety Notes
- This medication works best as part of a complete diabetes care plan — including diet, exercise, and blood sugar monitoring.
- Not recommended during pregnancy or breastfeeding without medical supervision.
- Seek urgent medical help if you experience unusual fatigue, cold hands/feet, or breathing problems.
Final Thoughts
Alogliptin and Metformin provide a strong two-pronged approach for managing type 2 diabetes — improving insulin response and lowering liver sugar production. If prescribed, be consistent with your doses and pair it with healthy lifestyle choices for best results.
Always discuss with your doctor before making changes to your medication routine or if you experience any side effects.