Aceclofenac and Paracetamol (also known as Acetaminophen) are commonly prescribed together to manage a variety of painful and inflammatory conditions. This combination offers enhanced pain relief by targeting both inflammation and fever-related symptoms.
What is Aceclofenac?
- Drug Class: Nonsteroidal anti-inflammatory drug (NSAID)
- How It Works: Blocks the cyclooxygenase (COX) enzyme, which reduces prostaglandin production. Prostaglandins cause pain, inflammation, and swelling.
- Medical Uses: Used to treat osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and general joint or muscle pain.
- Possible Side Effects: Nausea, stomach discomfort, dizziness, and — with prolonged use — liver or kidney complications.
What is Paracetamol (Acetaminophen)?
- Drug Class: Analgesic (pain reliever) and antipyretic (fever reducer)
- Mechanism of Action: It acts on the central nervous system to block pain signals by inhibiting prostaglandin synthesis. Has minimal anti-inflammatory properties.
- Medical Uses: It is commonly used for mild to moderate pain (e.g., headaches, back pain, menstrual cramps) and to reduce fever.
- Side Effects: Well-tolerated when used appropriately. An overdose can lead to severe liver toxicity.
Benefits of Combining Aceclofenac and Paracetamol
The combination provides a broader spectrum of pain relief:
- Aceclofenac reduces inflammation
- Paracetamol enhances pain relief and controls fever
Together, they offer more effective symptom control for both inflammatory and non-inflammatory conditions.
Common Conditions Treated
Doctors commonly prescribe this combination for:
- Osteoarthritis
- Rheumatoid arthritis
- Dental pain
- Musculoskeletal pain and post-surgical discomfort
Standard Dosage and Administration
This combination contains 100 mg of Aceclofenac and 500 mg of Paracetamol. Usually taken once or twice daily with meals to reduce stomach irritation. Always follow your doctor’s dosage recommendations.
Important Precautions
- Avoid alcohol, since it can raise the risk of liver damage.
- Not suitable for individuals with:
- Severe liver or kidney disease
- Peptic ulcers
- NSAID allergies
- Asthma triggered by NSAIDs
- Pregnant or breastfeeding? Consult your healthcare provider before use.
Potential Side Effects
Common Side Effects:
- Nausea
- Stomach upset
- Drowsiness or dizziness
Serious Side Effects:
- Liver toxicity (from Paracetamol overdose)
- Gastrointestinal bleeding or ulcers (due to Aceclofenac)
Final Advice
Only use Aceclofenac + Paracetamol under medical supervision. Self-medication can lead to dangerous side effects or drug interactions. Always inform your doctor about any other medications or supplements you’re taking before starting this combination.