Progesterone

Used in hormone replacement therapy (HRT), treatment of menstrual disorders, luteal phase support in infertility, and to prevent endometrial hyperplasia during estrogen therapy.

Drowsiness, breast tenderness, mood swings, bloating, headache.

Use cautiously in patients with depression, cardiovascular disease, or liver dysfunction; monitor if used long-term.

Known or suspected breast or hormone-sensitive cancer, active thrombophlebitis or thromboembolic disorders, liver disease, undiagnosed vaginal bleeding.

Oral: typically 100–200 mg daily; Vaginal/IM: dosage varies by indication and formulation.

Mexico, Brazil

Oral capsules, vaginal gels/tablets, intramuscular injections, transdermal creams.