Medroxyprogesterone

Used for contraception, treatment of abnormal uterine bleeding, endometriosis, secondary amenorrhea, and as part of hormone replacement therapy (HRT).

Weight gain, menstrual changes, headache, mood swings, decreased bone mineral density

Monitor bone health during long-term use; use cautiously in patients with a history of thromboembolism or depression.

Pregnancy, active thromboembolic disorders, liver disease, known or suspected breast or genital cancers.

Oral: 2.5–10 mg daily; IM injection: 150 mg every 3 months for contraception; Subcutaneous: 104 mg every 3 months.

Mexico, Brazil, Argentina

Oral tablets, intramuscular injection (Depo-Provera), subcutaneous injection.