Sacubitril + Valsartan
Composition
Fixed-dose combination of Sacubitril and Valsartan, typically available as 24/26 mg, 49/51 mg, and 97/103 mg tablets.
Indications
Used for the treatment of heart failure with reduced ejection fraction (HFrEF) to reduce the risk of cardiovascular death and hospitalization.
Side effects
Hypotension, hyperkalemia, dizziness, renal impairment, cough.
Precautions
Monitor blood pressure, renal function, and potassium levels; avoid use with ACE inhibitors or in patients with angioedema history.
Contraindications
History of angioedema with ACEi/ARB, concomitant ACE inhibitor use, pregnancy, severe hepatic impairment.
Dosage and administration
Start with 49/51 mg twice daily; adjust based on tolerance and renal function; lower starting dose for certain patients.
Countries
Exported to Brazil, Chile, Guatemala.
Available Forms
Oral film-coated tablets (24/26 mg, 49/51 mg, 97/103 mg).