Riociguat

Used to treat pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) to improve exercise capacity and delay clinical worsening.

Headache, dizziness, hypotension, gastrointestinal discomfort, nausea.

Monitor blood pressure regularly; avoid in pregnancy; use cautiously in patients with bleeding risk.

Pregnancy, concurrent use with nitrates or nitric oxide donors, hypersensitivity to Riociguat.

Start at 1 mg three times daily; adjust gradually based on blood pressure and tolerance (max 2.5 mg three times daily).

Oral tablets.